Cardiovascular disease.

Randomised, placebo-controlled trials possess obviously demonstrated that statins prevent heart disease and stroke in patients with and without a history of coronary disease . The latest UK Heart Prevention Research has created new interest by displaying that statins prevent cardiovascular disease in high risk individuals with baseline cholesterol readings only 3.5 mmol/L. That is a far cry from a few years back when cholesterol levels were regarded as probably deserving treatment only once they were greater than 6.5 mmol/L..The framework of EGCG resembles methotrexate which kills cancer tumor cells by binding to, and inactivating, the enzyme dihydrofolate reductase . The research team found that EGCG also binds strongly to DHFR and stops it functioning. DHFR is vital to DNA synthesis in both tumour and regular cells. However tumour cells grow and divide more quickly than normal cells, processes requiring more DNA synthesis and for that reason higher levels of DHFR activity. A variety of therapeutic agents, called antifolates, exploit the difference in DHFR dependence on normal and cancerous cellular material to selectively kill cancer cells.

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